3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

Base Information

Chemical Name:3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide
CAS No.:1415983-68-4
Molecular Formula:C₂₄H₂₉F₆N₇O
Molecular Weight:545.531
Hs Code.:

Synonyms:3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

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Chemical Property of 3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

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Technology Process of 3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

There total 5 articles about 3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415983-62-8
3-amino-N-(3-aminopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

: 1H-1,2,4-triazole-1-carboximidamide monohydrochloride

: 1415983-68-4
3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.09.048

Reference yield:

: 1202779-11-0
C₂₅H₂₇F₆NO₄

: 1415983-68-4
3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / 1,4-dioxane / 18 h / 100 °C

2.1: fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 168 h / 20 °C

3.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane; water / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With chlorotriisopropylsilane; water; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.09.048

Reference yield:

: 1202779-23-4
C₂₄H₂₅F₆NO₄

: 1415983-68-4
3-guanidino-N-(3-guanidinopropyl)-2,2-bis(4-(trifluoromethyl)benzyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 168 h / 20 °C

2.1: trifluoroacetic acid; chlorotriisopropylsilane / dichloromethane; water / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With chlorotriisopropylsilane; N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.09.048