4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

Base Information

Chemical Name:4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol
CAS No.:1132879-15-2
Molecular Formula:C₂₂H₃₂N₂O₂S
Molecular Weight:388.574
Hs Code.:

Synonyms:4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

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Chemical Property of 4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

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Technology Process of 4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

There total 4 articles about 4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

: 1132879-15-2
4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

Guidance literature:

Reference yield:

: 1132879-16-3
9H-fluoren-9-ylmethyl {4-[4-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3-thiazol-2-yl]tetrahydro-2H-pyran-4-yl}carbamate

: 1132879-15-2
4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

Guidance literature:: With diethylamine; In tetrahydrofuran; at 20 - 50 ℃;
DOI:10.1016/j.bmcl.2014.11.003

Reference yield:

: 285996-72-7
Fmoc-4-aminotetrahydropyran-4-carboxylic acid

: 1132879-15-2
4-[2-(4-aminotetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol

Guidance literature:: Multi-step reaction with 4 steps

1: N-hydroxybenzotriazole ammonium salt; N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

2: diphosphorus pentasulfide; sodium hydrogencarbonate / 1,2-dimethoxyethane / 0 - 20 °C

3: 12 h / 20 °C / Reflux

4: diethylamine / tetrahydrofuran / 20 - 50 °C

With diphosphorus pentasulfide; N-hydroxybenzotriazole ammonium salt; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.11.003