(S)-2-AMINO-3-QUINOLIN-2-YL-PROPIONIC ACID

Base Information

• Chemical Name: (S)-2-AMINO-3-QUINOLIN-2-YL-PROPIONIC ACID
• CAS No.: 161513-46-8
• Molecular Formula: C12H12 N2 O2
• Molecular Weight: 216.24
• Hs Code.: 2933499090
• Mol file: 161513-46-8.mol

Synonyms:2-Quinolinepropanoicacid, a-amino-, (S)-

Chemical Property of (S)-2-AMINO-3-QUINOLIN-2-YL-PROPIONIC ACID

Chemical Property:

• Boiling Point: 404.7±35.0 °C(Predicted)
• PKA: 1.71±0.10(Predicted)
• PSA: 76.21000
• Density: 1.312±0.06 g/cm3(Predicted)
• LogP: 1.88950
• Storage Temp.: 2-8°C

Purity/Quality:

98% Min ^*data from raw suppliers

(S)-2-Amino-3-quinolin-2-yl-propionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-2-Amino-3-quinolin-2-yl-propionic Acid can be used in antifouling coating material.

Technology Process of (S)-2-AMINO-3-QUINOLIN-2-YL-PROPIONIC ACID

There total 1 articles about (S)-2-AMINO-3-QUINOLIN-2-YL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5S)-(+)-5-(2'-quinolylmethyl)-2-tert-butyl-1-tert-butoxycarbonyl-3-methyl-4-imidazolidinone (161453-32-3) → (S)-(+)-2-amino-3-(2'-quinolyl)propionic acid (161513-46-8)

Guidance literature:

With hydrogenchloride; Dowex 50W X₈; acetic acid; trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, from 0 deg C to RT, overnight, 2.) toluene, 100 deg C, 20 h;

DOI:10.1016/0957-4166(94)80088-X

Reference yield: 87.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-(+)-2-amino-3-(2'-quinolyl)propionic acid (161513-46-8) → (S)-(-)-2-tert-butyloxycarbonylamino-3-(2'-quinolyl)propionic acid (170157-64-9,401813-49-8,161453-37-8)

Guidance literature:

With triethylamine; In methanol; for 0.5h;

DOI:10.1016/0957-4166(94)80088-X

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + (S)-(+)-2-amino-3-(2'-quinolyl)propionic acid (161513-46-8) → Ts-Ala(2'-quinolyl)-OH (1197204-84-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h;

upstream raw materials:

(2S,5S)-(+)-5-(2'-quinolylmethyl)-2-tert-butyl-1-tert-butoxycarbonyl-3-methyl-4-imidazolidinone

Downstream raw materials:

(S)-(-)-2-tert-butyloxycarbonylamino-3-(2'-quinolyl)propionic acid

Ts-Ala(2'-quinolyl)-Val-Oallyl

Ts-Ala(2'-quinolyl)-Val-OH

Ts-Ala(2'-quinolyl)-OH