2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Base Information

Chemical Name:2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole
CAS No.:1270018-00-2
Molecular Formula:C₄₁H₃₆ClF₂NO₅S
Molecular Weight:728.256
Hs Code.:

Synonyms:2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Suppliers and Price of 2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

There total 3 articles about 2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1270017-98-5
(2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-2-carbaldehyde

: 1270018-00-2
2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2010.11.115

Reference yield:

: 1270017-96-3
((2R,3R,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-2-yl)methanol

: 1270018-00-2
2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 15 h / -78 - 20 °C

With diethylamino-sulfur trifluoride; Dess-Martin periodane; In dichloromethane;
DOI:10.1016/j.bmcl.2010.11.115

Reference yield:

: 1352714-49-8
C₄₃H₄₀ClNO₇S

: 1270018-00-2
2-(2-chloro-5-((2S,3S,4R,5S,6S)-3,4,5-tris(benzyloxy)-6-(difluoromethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; methanol / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: diethylamino-sulfur trifluoride / dichloromethane / 15 h / 20 °C / Inert atmosphere

With methanol; diethylamino-sulfur trifluoride; sodium methylate; Dess-Martin periodane; In dichloromethane;