(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Base Information

Chemical Name:(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one
CAS No.:1446489-29-7
Molecular Formula:C₂₄H₃₂O₅
Molecular Weight:400.515
Hs Code.:

Synonyms:(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Suppliers and Price of (1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

There total 17 articles about (1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1446489-27-5
(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-bis{[tert-butyl(dimethyl)silyl]oxy}-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

: 1446489-29-7
(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Guidance literature:: With triethylamine tris(hydrogen fluoride); In acetonitrile; at 60 ℃; for 17h;
DOI:10.1021/jm400615g

Reference yield:

: 1446488-81-8
ethyl (2E)-7-[(1-Phenyl-1H-tetrazol-5-yl)thio]hept-2-enoate

: 1446489-29-7
(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 °C

2.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / ethanol / 16 h / 0 - 20 °C

4.1: potassium hexamethylsilazane / toluene; 1,2-dimethoxyethane / 18 h / -78 - 20 °C

5.1: potassium hydrogencarbonate; palladium di-μ-chlorobis (η-allyl) / water; N,N-dimethyl-formamide / 3 h / 20 °C

6.1: methanol; sodium hydroxide / tetrahydrofuran / 1 h / 60 °C

7.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.08 h / 70 °C / Inert atmosphere

7.2: 0.33 h / 0 °C / Inert atmosphere

8.1: silver(l) oxide; tetra-(n-butyl)ammonium iodide / 7 h / 20 °C

9.1: triethylamine tris(hydrogen fluoride) / acetonitrile / 17 h / 60 °C

With pyridine; methanol; hexaammonium heptamolybdate tetrahydrate; palladium di-μ-chlorobis (η-allyl); dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; diisobutylaluminium hydride; potassium hydrogencarbonate; triethylamine tris(hydrogen fluoride); 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 7.1: |Suzuki-Miyaura Coupling / 7.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400615g

Reference yield:

: 1446488-71-6
methyl (2E,4R)-4-[(tert-butyldimethylsilyl)oxy]-4-{(1'R,2'S,4'S)-4'-[(tert-butyldimethylsilyl)oxy]-2'-[(1''E,6''S)-6''-hydroxyhept-1''-en-1''-yl]cyclopentyl}but-2-enoate

: 1446489-29-7
(1R,6R,11aS,13S,14aR)-6-[2-(benzyloxy)ethyl]-1,13-dihydroxy-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; acetone / 3 h / 20 °C

2.1: sodium periodate / water; tetrahydrofuran / 2 h / 20 °C

3.1: potassium hexamethylsilazane / toluene; 1,2-dimethoxyethane / 18 h / -78 - 20 °C

4.1: potassium hydrogencarbonate; palladium di-μ-chlorobis (η-allyl) / water; N,N-dimethyl-formamide / 3 h / 20 °C

5.1: methanol; sodium hydroxide / tetrahydrofuran / 1 h / 60 °C

6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.08 h / 70 °C / Inert atmosphere

6.2: 0.33 h / 0 °C / Inert atmosphere

7.1: silver(l) oxide; tetra-(n-butyl)ammonium iodide / 7 h / 20 °C

8.1: triethylamine tris(hydrogen fluoride) / acetonitrile / 17 h / 60 °C

With methanol; potassium osmate(VI) dihydrate; sodium periodate; palladium di-μ-chlorobis (η-allyl); tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; potassium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine tris(hydrogen fluoride); 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; silver(l) oxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; 6.1: |Suzuki-Miyaura Coupling / 6.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400615g