2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

Base Information

Chemical Name:2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide
CAS No.:1344141-88-3
Molecular Formula:C₂₃H₁₇BrF₃N₃O₄S
Molecular Weight:568.371
Hs Code.:

Synonyms:2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

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Chemical Property of 2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

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Technology Process of 2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

There total 5 articles about 2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1344141-65-6
3-(3-aminobenzylamino)-N-(4-trifluoromethoxyphenyl)thiophene-2-carboxamide

: 598-21-0
2-Bromoacetyl bromide

: 1344141-88-3
2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

Guidance literature:: 3-(3-aminobenzylamino)-N-(4-trifluoromethoxyphenyl)thiophene-2-carboxamide; With sodium hydrogencarbonate; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

2-Bromoacetyl bromide; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.bmcl.2011.08.070

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 1344141-88-3
2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylaluminum / toluene / 16 h / 20 °C / Inert atmosphere

1.2: 24 h / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate; trifluoroacetic acid / ethyl acetate

3.1: platinum(IV) oxide; hydrogen / methanol / 0.5 h / 20 °C / 2068.65 Torr

4.1: sodium hydrogencarbonate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

4.2: 0 °C

With platinum(IV) oxide; sodium tetrahydroborate; hydrogen; trimethylaluminum; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.08.070

Reference yield:

: 728033-97-4
3-smino-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide

: 1344141-88-3
2-bromo-N-(3-((2,5-dioxo-4-(4-(trifluoromethoxy)phenyl)-2,3,4,5-tetrahydro-1H-thieno[3,2-e][1,4]diazepin-1-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; trifluoroacetic acid / ethyl acetate

2.1: platinum(IV) oxide; hydrogen / methanol / 0.5 h / 20 °C / 2068.65 Torr

3.1: sodium hydrogencarbonate / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.2: 0 °C

With platinum(IV) oxide; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1016/j.bmcl.2011.08.070