(Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide
• CAS No.: 1309600-02-9
• Molecular Formula: C₁₅H₁₉NO₃S
• Molecular Weight: 293.387
• Mol file: 1309600-02-9.mol

Synonyms:(Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Chemical Property of (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide

There total 3 articles about (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C21H33NO3SSi (1372714-62-9) → (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide (1309600-02-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere;

DOI:10.1055/s-0031-1290314

Reference yield:

C17H21NO4S → (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide (1309600-02-9)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201703380

Reference yield:

4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide (286376-23-6) → (Z)-N-(but-2-yn-1-yl)-N-(4-hydroxybut-2-en-1-yl)-4-methylbenzenesulfonamide (1309600-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran;

DOI:10.1055/s-0031-1290314

upstream raw materials:

C₂₁H₃₃NO₃SSi

4-methyl-N-(prop-1-yn-1-yl)benzenesulfonamide

Downstream raw materials:

C₁₅H₁₉NO₃S