(Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester

Base Information

• Chemical Name: (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester
• CAS No.: 709631-38-9
• Molecular Formula: C₁₁H₁₁IO₃
• Molecular Weight: 318.111
• Mol file: 709631-38-9.mol

Synonyms:(Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester

Chemical Property of (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester

There total 1 articles about (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-hydroxy-4-phenyl-but-2-ynoic acid methyl ester (33553-90-1) → (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester (709631-38-9)

Guidance literature:

4-hydroxy-4-phenyl-but-2-ynoic acid methyl ester; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at -72 ℃; for 0.666667h;

With iodine; In tetrahydrofuran; toluene; at -72 - -10 ℃; for 0.833333h;

DOI:10.1021/ol0495366

Reference yield: 64.0%

hex-1-yne (693-02-7) + (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester (709631-38-9) → 2-[2-Hydroxy-2-phenyl-eth-(E)-ylidene]-oct-3-ynoic acid methyl ester

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine; at 23 ℃; for 0.416667h;

DOI:10.1021/ol0495366

Reference yield: 45.0%

tri-n-butyl(vinyl)tin (7486-35-3) + (Z)-4-Hydroxy-2-iodo-4-phenyl-but-2-enoic acid methyl ester (709631-38-9) → (E)-4-Hydroxy-4-phenyl-2-vinyl-but-2-enoic acid methyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 48h;

DOI:10.1021/ol0495366

upstream raw materials:

4-hydroxy-4-phenyl-but-2-ynoic acid methyl ester