(2'-hydroxycyclohexyl)phenylphenylsulphonylmethane

Base Information

• Chemical Name: (2'-hydroxycyclohexyl)phenylphenylsulphonylmethane
• CAS No.: 130739-12-7
• Molecular Formula: C₁₉H₂₂O₃S
• Molecular Weight: 330.448
• Mol file: 130739-12-7.mol

Synonyms:(2'-hydroxycyclohexyl)phenylphenylsulphonylmethane

Chemical Property of (2'-hydroxycyclohexyl)phenylphenylsulphonylmethane

Chemical Property:

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Technology Process of (2'-hydroxycyclohexyl)phenylphenylsulphonylmethane

There total 1 articles about (2'-hydroxycyclohexyl)phenylphenylsulphonylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl phenyl sulfone (3112-88-7) + cyclohexane-1,2-epoxide (286-20-4) → (2'-hydroxycyclohexyl)phenylphenylsulphonylmethane (130739-12-7)

Guidance literature:

With n-butyllithium; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) THF, hexane, -74 deg C, 30 min, 2a.) -74 deg C, 1 h, 2b.) from -74 deg C to RT, 1.5 h;

Reference yield:

(2'-hydroxycyclohexyl)phenylphenylsulphonylmethane (130739-12-7) → 2-Benzylidenecyclohexanone (5682-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 2 h

2: DBU / CH₂Cl₂; diethyl ether / 3 h

With jones reagent; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; dichloromethane; acetone;

Reference yield:

(2'-hydroxycyclohexyl)phenylphenylsulphonylmethane (130739-12-7) → 2-(Benzenesulfonyl-phenyl-methyl)-cyclohexanone (448915-86-4)

Guidance literature:

With jones reagent; In acetone; for 2h;

upstream raw materials:

Benzyl phenyl sulfone

cyclohexane-1,2-epoxide

Downstream raw materials:

2-(Benzenesulfonyl-phenyl-methyl)-cyclohexanone

2-Benzylidenecyclohexanone

2-Benzyliden-cyclohexanon-(1)-<2,4-dinitro-phenylhydrazon>

Refernces