2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol

Base Information

• Chemical Name: 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol
• CAS No.: 299411-65-7
• Molecular Formula: C₁₆H₂₂FN₃OSi
• Molecular Weight: 319.454
• Mol file: 299411-65-7.mol

Synonyms:2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol

Chemical Property of 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol

There total 2 articles about 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone (58905-21-8) + (1-bromoallyl)trimethylsilane (94397-40-7) → 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol (299411-65-7)

Guidance literature:

(1-bromoallyl)trimethylsilane; With aluminium; mercury dichloride; In diethyl ether; for 5h; Heating;

4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone; In diethyl ether; dichloromethane; at 20 ℃; for 1h;

DOI:10.1248/cpb.48.1148

Reference yield:

2-Chloro-4'-fluoroacetophenone (456-04-2) → 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol (299411-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72 percent / K₂CO₃ / acetonitrile / 5 h / 20 °C

2.1: Al; HgCl₂ / diethyl ether / 5 h / Heating

2.2: 51 percent / CH₂Cl₂; diethyl ether / 1 h / 20 °C

With potassium carbonate; aluminium; mercury dichloride; In diethyl ether; acetonitrile;

DOI:10.1248/cpb.48.1148

Reference yield: 93.0%

2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilylpent-4-en-2-ol (299411-65-7) → 2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-trimethylsilyl-2-pentanol

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 4h;

DOI:10.1248/cpb.48.1148

upstream raw materials:

4'-fluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone

(1-bromoallyl)trimethylsilane

2-Chloro-4'-fluoroacetophenone