tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

Base Information

Chemical Name:tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate
CAS No.:1256591-23-7
Molecular Formula:C₃₃H₃₄N₆O₆
Molecular Weight:610.67
Hs Code.:

Synonyms:tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

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Chemical Property of tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

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Technology Process of tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

There total 5 articles about tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1256591-07-7
2,6-bis(4-cyanophenoxy)nicotinic acid

: 1305711-15-2
tert-butyl (3-(4-aminopiperidin-1-yl)-3-oxopropyl)carbamate

: 1256591-23-7
tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

Guidance literature:: 2,6-bis(4-cyanophenoxy)nicotinic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 5 ℃; for 0.166667h;

tert-butyl (3-(4-aminopiperidin-1-yl)-3-oxopropyl)carbamate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ml400213v

Reference yield:

: 1256591-06-6
ethyl 2,6-bis(4-cyanophenoxy)nicotinate

: 1256591-23-7
tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 5 °C

2.2: 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400213v

Reference yield:

: 767-00-0
4-cyanophenol

: 1256591-23-7
tert-butyl (3-(4-(2,6-bis(4-cyanophenoxy)nicotinamido)piperidin-1-yl)-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 4 h / 75 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 5 °C

3.2: 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ml400213v