Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide

Base Information Edit
  • Chemical Name:(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
  • CAS No.:160970-64-9
  • Molecular Formula:C25H32F3N3O4
  • Molecular Weight:495.542
  • Hs Code.:
  • European Community (EC) Number:814-909-2
  • DSSTox Substance ID:DTXSID90870072
  • Pharos Ligand ID:BJB1Y5TPQGM9
  • ChEMBL ID:CHEMBL3187195
  • Mol file:160970-64-9.mol
(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide

Synonyms:160970-64-9;CHEMBL3187195;1-(3-Hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide;1-(3-Hydroxypropyl)-5-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide;(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide;1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-;SCHEMBL1533433;DTXSID90870072;PNCPYILNMDWPEY-UHFFFAOYSA-N;HMS3655O09;HMS3745O19;BCP07868;BDBM50173003;AKOS015896979;SB19320;NCGC00389564-01;FT-0674584;FT-0674585;FT-0687491;AB01566828_01;A855194;L000329;1-(3-Hydroxypropyl)-5-[2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide

Suppliers and Price of (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • American Custom Chemicals Corporation
  • 2,3-DIHYDRO-1-(3-HYDROXYPROPYL)-5-[2-[[2-[2-(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL]AMINO]PROPYL]-1H-INDOLE-7-CARBOXAMIDE 95.00%
  • 5MG
  • $ 499.37
Total 78 raw suppliers
Chemical Property of (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide Edit
Chemical Property:
  • Appearance/Colour:colorless to pink solid 
  • Vapor Pressure:2.58E-15mmHg at 25°C 
  • Refractive Index:1.552 
  • Boiling Point:601.4 °C at 760 mmHg 
  • PKA:14.85±0.10(Predicted) 
  • Flash Point:317.5 °C 
  • PSA:97.05000 
  • Density:1.249 g/cm3 
  • LogP:4.22730 
  • XLogP3:3.6
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:13
  • Exact Mass:495.23449100
  • Heavy Atom Count:35
  • Complexity:654
Purity/Quality:

99% *data from raw suppliers

2,3-DIHYDRO-1-(3-HYDROXYPROPYL)-5-[2-[[2-[2-(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL]AMINO]PROPYL]-1H-INDOLE-7-CARBOXAMIDE 95.00% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
Technology Process of (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide

There total 12 articles about (R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 5 steps
1: acetic anhydride / tetrahydrofuran / 24 h / 70 °C
2: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 48 h / 40 °C
3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C
4: sodium hydroxide; water / methanol / 2 h / 20 °C
5: sodium hydroxide; water; dihydrogen peroxide / dimethyl sulfoxide / 0 - 25 °C
With palladium 10% on activated carbon; water; hydrogen; dihydrogen peroxide; acetic anhydride; sodium tris(acetoxy)borohydride; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.5b02023
Guidance literature:
Multi-step reaction with 11 steps
1.1: triethylamine / dichloromethane / 8 h / 0 - 25 °C / Inert atmosphere
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 0 °C / Inert atmosphere
2.2: 2 h / 0 - 80 °C / Inert atmosphere
3.1: ammonium acetate; acetic acid / 4 h / 80 °C
4.1: sodium tetrahydroborate / dichloromethane; methanol / 1 h / 0 - 25 °C
5.1: trichlorophosphate / 1 h / 0 °C / Inert atmosphere
5.2: 2 h / 0 - 80 °C / Inert atmosphere
6.1: hydroxylamine hydrochloride; pyridine / tetrahydrofuran / 12 h / 70 °C
7.1: acetic anhydride / tetrahydrofuran / 24 h / 70 °C
8.1: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 48 h / 40 °C
9.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 20 °C
10.1: sodium hydroxide; water / methanol / 2 h / 20 °C
11.1: sodium hydroxide; water; dihydrogen peroxide / dimethyl sulfoxide / 0 - 25 °C
With pyridine; sodium tetrahydroborate; palladium 10% on activated carbon; hydroxylamine hydrochloride; ammonium acetate; water; hydrogen; dihydrogen peroxide; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation / 5.1: |Vilsmeier-Haack Formylation / 5.2: |Vilsmeier-Haack Formylation;
DOI:10.1021/acs.jmedchem.5b02023
Refernces Edit
Post RFQ for Price