(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

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Chemical Name:(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione
CAS No.:886883-46-1
Molecular Formula:C₃₂H₃₁N₃O₅
Molecular Weight:537.615
Hs Code.:

Synonyms:(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

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Chemical Property of (S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

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Technology Process of (S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

There total 9 articles about (S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886883-45-0
(S)-3-bromo-1-(2,4-dimethoxy-benzyl)-4-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-pyrrole-2,5-dione

: 62-53-3
aniline

: 886883-46-1
(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

Guidance literature:: With caesium carbonate; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; at 105 ℃; for 14h;
DOI:10.1021/ol060485h

Reference yield:

: 886883-34-7
3-chloro-2-[(methyloxy)methyl]-1-propene

: 886883-46-1
(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / potassium carbonate / dimethylformamide / 12 h / 50 °C

2: 85 percent / benzene / 12 h / 20 °C

3: [RhCl(coe)2]2; [(R)-1,1'-binaphthyl-2,2'-diyldioxy]-{[(S)-Ph(Me)CH]2N}P / toluene / 21 h / 90 °C

4: acetic acid / tetrahydrofuran / 6 h / 20 °C

5: RhCl(dppp)2 / xylene / Heating

6: potassium carbonate / tetrahydrofuran / 132 h / 85 °C

7: cesium carbonate / palladium(II) acetate; (R)-BINAP / toluene / 14 h / 105 °C

With potassium carbonate; caesium carbonate; acetic acid; [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; [Rh(1,3-bis(diphenylphosphino)propane)₂]Cl; [RhCl(coe)2]2; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; xylene; benzene;
DOI:10.1021/ol060485h

Reference yield:

: 886883-44-9
(S)-2-methoxymethyl-2,3-dihydro-1H-3a-aza-cyclopenta[a]indene

: 886883-46-1
(S)-1-(2,4-dimethoxy-benzyl)-3-(2-methoxymethyl-2,3-dihydro-1H-3a-azacyclopenta[a]inden-8-yl)-4-phenylamino-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran / 132 h / 85 °C

2: cesium carbonate / palladium(II) acetate; (R)-BINAP / toluene / 14 h / 105 °C

With potassium carbonate; caesium carbonate; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; toluene;
DOI:10.1021/ol060485h