(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

Base Information

Chemical Name:(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester
CAS No.:1268868-63-8
Molecular Formula:C₃₁H₄₄O₆Si
Molecular Weight:540.772
Hs Code.:

Synonyms:(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

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Chemical Property of (1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

Chemical Property:

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Technology Process of (1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

There total 3 articles about (1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268868-61-6
(4R,6S)-4-benzyloxy-6-[(tert-butyldimethylsilyl)oxy]-3-(2,3-dimethoxyphenyl)-2-cyclohexen-1-one

: 1268868-63-8
(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: cerium(III) chloride heptahydrate / dichloromethane; methanol / 1 h / 20 °C

1.2: 0.5 h / -78 °C

2.1: 2-hydroxynitrobenzene / 52 h / 140 °C / Sealed tube; Inert atmosphere

With cerium(III) chloride heptahydrate; 2-hydroxynitrobenzene; In methanol; dichloromethane;
DOI:10.3987/COM-10-S(E)27

Reference yield:

: C₂₇H₃₈O₅Si

: 1268868-63-8
(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane / 1 h / 60 °C / Molecular sieve

1.2: Silica gel / 1 h / 20 °C

2.1: cerium(III) chloride heptahydrate / dichloromethane; methanol / 1 h / 20 °C

2.2: 0.5 h / -78 °C

3.1: 2-hydroxynitrobenzene / 52 h / 140 °C / Sealed tube; Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; cerium(III) chloride heptahydrate; 2-hydroxynitrobenzene; In methanol; dichloromethane;
DOI:10.3987/COM-10-S(E)27

Reference yield:

: 1268868-62-7
(1S,4R,6S)-4-benzyloxy-6-[(tert-butyldimethylsilyl)oxy]-3-(2,3-dimethoxyphenyl)-2-cyclohexen-1-ol

: 78-39-7
Triethyl orthoacetate

: 1268868-63-8
(1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester

Guidance literature:: With 2-hydroxynitrobenzene; at 140 ℃; for 52h; stereoselective reaction; Sealed tube; Inert atmosphere;
DOI:10.3987/COM-10-S(E)27