2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

Base Information

Chemical Name:2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester
CAS No.:162358-55-6
Molecular Formula:C₂₅H₄₀N₂O₅
Molecular Weight:448.603
Hs Code.:

Synonyms:2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

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Chemical Property of 2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

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Technology Process of 2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

There total 9 articles about 2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 162358-54-5
4-(N-methylheptylamino)phenethyl iodide

: 162358-55-6
2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h;

4-(N-methylheptylamino)phenethyl iodide; In ethanol; at 65 ℃; for 3h; Further stages.;
DOI:10.1021/jm000173z

Reference yield:

: 2528-61-2
Heptanoic acid chloride

: 162358-55-6
2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 52 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

2.1: p-TsOH*H₂O / tetrahydrofuran; CH₂Cl₂ / 7 h / 20 °C

3.1: 5.95 g / potassium tert-butoxide / 1,2-dimethoxy-ethane / 1 h / 60 °C

4.1: BH₃*THF / tetrahydrofuran / 3 h / 0 °C

5.1: 3.22 g / p-TsOH*H₂O; MeOH / 3 h / 20 °C

6.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

7.1: 2.58 g / NaI / butan-2-one / 2 h / Heating

8.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

8.2: ethanol / 3 h / 65 °C

With methanol; borane-THF; potassium tert-butylate; sodium ethanolate; toluene-4-sulfonic acid; triethylamine; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; butanone; 1.1: Acylation / 2.1: Addition / 3.1: Methylation / 4.1: Reduction / 5.1: methanolysis / 6.1: mesylation / 7.1: Iodination / 8.1: Metallation / 8.2: Alkylation;
DOI:10.1021/jm000173z

Reference yield:

: 162358-52-3
4-(N-methylheptylamino)phenethyl alcohol

: 162358-55-6
2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2.1: 2.58 g / NaI / butan-2-one / 2 h / Heating

3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

3.2: ethanol / 3 h / 65 °C

With sodium ethanolate; triethylamine; sodium iodide; In ethanol; dichloromethane; butanone; 1.1: mesylation / 2.1: Iodination / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1021/jm000173z