N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

Base Information

Chemical Name:N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide
CAS No.:1359659-10-1
Molecular Formula:C₁₇H₂₀N₂O₃
Molecular Weight:300.357
Hs Code.:

Synonyms:N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

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Chemical Property of N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

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Technology Process of N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

There total 5 articles about N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: N-[(3S)-2-oxoazetidin-3-yl]-2-phenoxyacetamide

: 106-95-6
allyl bromide

: 1359659-10-1
N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/asia.201100732

Reference yield:

: 1104761-72-9
(2S)-3-hydroxy-2-(2-phenoxyacetamido)propanoic acid

: 1359659-10-1
N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

3: hydrogen / methanol; water; ethyl acetate / 12 h / 20 °C / 760.05 Torr

4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogen; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/asia.201100732

Reference yield:

: 1359659-07-6
(2S)-N-(benzyloxy)-3-hydroxy-2-(2-phenoxyacetamido)propanamide

: 1359659-10-1
N-[(3S)-2-oxo-1-(prop-2-en-1-yl)azetidin-3-yl]-2-phenoxy-N-(prop-2-en-1-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; triphenylphosphine / tetrachloromethane; acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

2: hydrogen / methanol; water; ethyl acetate / 12 h / 20 °C / 760.05 Torr

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogen; sodium hydride; triethylamine; triphenylphosphine; In methanol; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1002/asia.201100732