Carbamic acid, [(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 160801-74-1
• Molecular Formula: C10H19 N O3
• Molecular Weight: 201.266
• Hs Code.: 2924199090
• Mol file: 160801-74-1.mol

Synonyms:Carbamicacid, (1-formylbutyl)-, 1,1-dimethylethyl ester, (S)-; Carbamic acid,[(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI);N-tert-Butoxycarbonyl-L-norvalinal

Chemical Property of Carbamic acid, [(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 55.40000
• LogP: 2.26960

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI)

There total 11 articles about Carbamic acid, [(1S)-1-formylbutyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate (116611-57-5,116611-55-3) → (2S)-2-(1,1-dimethylethoxycarbonylamino)pentanal (160801-74-1)

Guidance literature:

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at -10 ℃;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield: 91.0%

methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norvalinate (64896-37-3) → (2S)-2-(1,1-dimethylethoxycarbonylamino)pentanal (160801-74-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 1.5h;

DOI:10.1021/acs.joc.7b00969

Reference yield: 90.0%

(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate (160801-73-0) → (2S)-2-(1,1-dimethylethoxycarbonylamino)pentanal (160801-74-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 5 ℃; for 0.5h;

DOI:10.1021/jm00044a013

upstream raw materials:

(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopentan-2-ylcarbamate

tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate

L-Norvaline

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-3-Amino-2-hydroxy-hexanoic acid

(3S)-3-(tert-butoxycarbonylamino)-2-hydroxyhexanoic acid

Boc-D-Phe-Leu-Nva-CONH-CH₂CH₃

Boc-Phe-Leu-Nva-CONH-CH₂CH₃