Technology Process of (2,2',6,6'-tetrakis(trideuteriomethyl)-3,3',4,4',5,5'-hexamethyldiphenyl)diazomethane
There total 11 articles about (2,2',6,6'-tetrakis(trideuteriomethyl)-3,3',4,4',5,5'-hexamethyldiphenyl)diazomethane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
at -30 - -10 ℃;
Yield given;
DOI:10.1021/ja9635903
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 60 percent / dimethylformamide / Heating
2: 98 percent / H2SO4 / H2O / 48 h / Heating
3: 40 percent / H2SO4 / Heating
4: 90 percent / LiAlD4 / tetrahydrofuran / Heating
5: 73 percent / PBr3 / dioxane / Ambient temperature
6: 99 percent / LiAlD4 / tetrahydrofuran / Heating
7: 60 percent / Br2, Fe/I2 / CCl4 / 1 h / Ambient temperature
8: 81 percent / dimethylformamide / Heating
9: 1.) n-BuLi / 1.) n-hexane, 2.) n-hexane
10: N2O4, sodium acetate / CCl4 / 1 h / 5 - 10 °C
11: LiAlH4 / diethyl ether / -30 - -10 °C
With
lithium aluminium tetrahydride; n-butyllithium; lithium aluminium deuteride; sulfuric acid; bromine; iodine; sodium acetate; phosphorus tribromide; dinitrogen tetraoxide; iron;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/ja9635903
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 98 percent / H2SO4 / H2O / 48 h / Heating
2: 40 percent / H2SO4 / Heating
3: 90 percent / LiAlD4 / tetrahydrofuran / Heating
4: 73 percent / PBr3 / dioxane / Ambient temperature
5: 99 percent / LiAlD4 / tetrahydrofuran / Heating
6: 60 percent / Br2, Fe/I2 / CCl4 / 1 h / Ambient temperature
7: 81 percent / dimethylformamide / Heating
8: 1.) n-BuLi / 1.) n-hexane, 2.) n-hexane
9: N2O4, sodium acetate / CCl4 / 1 h / 5 - 10 °C
10: LiAlH4 / diethyl ether / -30 - -10 °C
With
lithium aluminium tetrahydride; n-butyllithium; lithium aluminium deuteride; sulfuric acid; bromine; iodine; sodium acetate; phosphorus tribromide; dinitrogen tetraoxide; iron;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/ja9635903
