(3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one

Base Information

• Chemical Name: (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one
• CAS No.: 944442-22-2
• Molecular Formula: C₂₀H₂₃NO₂
• Molecular Weight: 309.408

Synonyms:(3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one

Chemical Property of (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one

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Technology Process of (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one

There total 10 articles about (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S,3S,αR)-1-(pyrrolidin-1'-yl)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-hydroxybutan-1-one → (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one (944442-22-2)

Guidance literature:

With hydrogenchloride; at 20 ℃;

DOI:10.1016/j.tet.2007.03.026

Reference yield: 80.0%

(2S,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one (944410-93-9) → (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one (944442-22-2)

Guidance literature:

With hydrogenchloride; potassium fluoride;

DOI:10.1016/j.tet.2007.03.026

Reference yield: 77.0%

ethyl (3S,αR)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate → (3S,4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]-3-methyldihydrofuran-2(3H)-one (944442-22-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.tet.2007.03.026

upstream raw materials:

methyl (2S,3S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)butanoate

methyl (2R,3S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)butanoate

(2S,3S,αR)-1-(pyrrolidin-1'-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)-2-methylbutan-1-one

(4S,αR)-4-[N-benzyl-N-(α-methylbenzyl)amino]dihydrofuran-2(3H)-one

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