4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene

Base Information

• Chemical Name: 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene
• CAS No.: 178486-13-0
• Molecular Formula: C₂₇H₃₁BrO₃
• Molecular Weight: 483.445
• Mol file: 178486-13-0.mol

Synonyms:4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene

Chemical Property of 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene

There total 4 articles about 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,5-dibromo-pentane (111-24-0) + 2-<3,4-bis(benzyloxy)phenyl>ethanol (96826-11-8) → 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene (178486-13-0)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.07.053

Reference yield:

1,5-dibromo-pentane (111-24-0) + 2-<3,4-bis(benzyloxy)phenyl>ethanol (96826-11-8) → 6-[2-[3,4-di(phenylmethoxy)phenyl]ethoxy]hexanoic acid (178486-12-9) + 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene (178486-13-0)

Guidance literature:

With NaH; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

benzyl chloride (100-44-7) → 4-[2'-{(5''-bromopentyl)oxy}ethyl]1,2-dibenzyloxybenzene (178486-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 65 °C

2: sodium hydride / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; 2: |Williamson Ether Synthesis;

DOI:10.1016/j.ejmech.2021.113980

upstream raw materials:

1,5-dibromo-pentane

2-<3,4-bis(benzyloxy)phenyl>ethanol

benzyl chloride

hydroxytyrosol