dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Base Information

Chemical Name:dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate
CAS No.:362604-16-8
Molecular Formula:C₂₁H₂₂ClNO₅
Molecular Weight:403.862
Hs Code.:

Synonyms:dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Suppliers and Price of dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

There total 6 articles about dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 335293-23-7
3,4,5-trimethylphenylacetyl chloride

: 335293-15-7
dimethyl 6-amino-4-chloro-1,3-isophthalate

: 362604-16-8
dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Guidance literature:: In 1,2-dichloro-ethane; at 80 ℃; for 12h;
DOI:10.1021/jm000275p

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 362604-16-8
dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Guidance literature:: Multi-step reaction with 5 steps

1: I₂; Ag₂SO₄ / methanol / 0.75 h / 20 °C

2: 93 percent / 1,2-dichloro-ethane / 3 h / 80 °C

3: 74 percent / Et₃N; (PPh₃)2PdCl₂ / dimethylformamide / 16 h / 80 °C / 760.05 Torr

4: 80 percent / H₂SO₄; MeOH / 1 h / Heating

5: 78 percent / 1,2-dichloro-ethane / 12 h / 80 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; sulfuric acid; iodine; silver sulfate; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000275p

Reference yield:

: 51719-67-6
3,4,5-trimethylphenylacetic acid

: 362604-16-8
dimethyl 6-N-(3,4,5-trimethylphenyl)acetylamino-4-chloro-1,3-isophthalate

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂ / 20 °C

2: 78 percent / 1,2-dichloro-ethane / 12 h / 80 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm000275p