(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

Base Information

Chemical Name:(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol
CAS No.:137845-34-2
Molecular Formula:C₂₁H₂₅NO₅S
Molecular Weight:403.499
Hs Code.:

Synonyms:(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

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Chemical Property of (2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

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Technology Process of (2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

There total 3 articles about (2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137845-38-6
(Z)-4-Phenylsulfanyl-3-trimethylsilanylmethyl-but-3-en-2-ol

: 137845-34-2
(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: C₅H₅N / CH₂Cl₂ / 0 °C

2: Pd(OAc)2, 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane / dioxane / 100 °C

3: 1.) MCPBA, 2.) (CH₃O)3P, Mg(OCH₃)2 / 2.) CH₃OH

With pyridine; palladium diacetate; 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane; magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja00023a094

Reference yield:

: 137845-09-1
Acetic acid (Z)-1-methyl-3-phenylsulfanyl-2-trimethylsilanylmethyl-allyl ester

: 137845-34-2
(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OAc)2, 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane / dioxane / 100 °C

2: 1.) MCPBA, 2.) (CH₃O)3P, Mg(OCH₃)2 / 2.) CH₃OH

With palladium diacetate; 2,4-bis<(4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)oxy>pentane; magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester; In 1,4-dioxane;
DOI:10.1021/ja00023a094

Reference yield:

: 137845-31-9
(2R,5R)-5-(3,4-Dimethoxy-phenyl)-2-methyl-3-phenylsulfanylmethyl-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole

: 137845-34-2
(2R,3S,5S)-2-(3,4-Dimethoxy-phenyl)-5-methyl-4-methylene-1-(toluene-4-sulfonyl)-pyrrolidin-3-ol

Guidance literature:: With magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester; Yield given. Multistep reaction; 2.) CH₃OH;
DOI:10.1021/ja00023a094