Pyridine, 3-hydrazino-2-methoxy- (9CI)

Base Information

• Chemical Name: Pyridine, 3-hydrazino-2-methoxy- (9CI)
• CAS No.: 160590-38-5
• Molecular Formula: C6H9 N3 O
• Molecular Weight: 139.157
• Mol file: 160590-38-5.mol

Synonyms:Pyridine,3-hydrazino-2-methoxy- (9CI); 3-Hydrazino-2-methoxypyridine

Chemical Property of Pyridine, 3-hydrazino-2-methoxy- (9CI)

Chemical Property:

• Boiling Point: 268.4±25.0 °C(Predicted)
• PKA: 4.20±0.10(Predicted)
• PSA: 60.17000
• Density: 1.228±0.06 g/cm3(Predicted)
• LogP: 1.14910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydrazinyl-2-methoxypyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 3-hydrazino-2-methoxy- (9CI)

There total 4 articles about Pyridine, 3-hydrazino-2-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methoxy-3-(2-methylhydrazinyl)pyridinium bistetrafluoroborate → 3-hydrazinyl-2-methoxypyridine (160590-38-5)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

DOI:10.1021/acs.joc.1c00203

Reference yield: 88.0%

3-amino-2-methoxypyridine (20265-38-7) → 3-hydrazinyl-2-methoxypyridine (160590-38-5)

Guidance literature:

3-amino-2-methoxypyridine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at 0 ℃; for 1.5h;

With potassium hydroxide; In water;

DOI:10.1021/ol902139r

Reference yield:

C12H19N3O3 → 3-hydrazinyl-2-methoxypyridine (160590-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / toluene / 1 h / 5 - 20 °C / Inert atmosphere

2: sodium hydroxide / water; dichloromethane

With boron trifluoride diethyl etherate; sodium hydroxide; In dichloromethane; water; toluene;

DOI:10.1021/acs.joc.1c00203

upstream raw materials:

3-amino-2-methoxypyridine

3-Bromo-2-methoxypyridine

Downstream raw materials:

7-methoxy-3-phenyl-1H-pyrrolo[2,3-c]pyridine

3-propyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

3-phenyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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