9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Base Information

Chemical Name:9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine
CAS No.:218601-31-1
Molecular Formula:C₂₆H₂₈ClFN₄OSSi
Molecular Weight:527.137
Hs Code.:

Synonyms:9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Suppliers and Price of 9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

There total 9 articles about 9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 87-42-3
6-chloropurine

: 218601-27-5
(3S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-ol

: 218601-31-1
9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 15h;
DOI:10.1039/a806562d

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 218601-31-1
9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / imidazole / dimethylformamide / 1 h / 0 °C

2: 54 percent / DAST / CH₂Cl₂ / 0.17 h / -4 °C

3: 100 percent / NaOMe / CH₂Cl₂; methanol / 2 h / 0 °C

4: 85 percent / DEAD, PPh₃ / tetrahydrofuran / 1.) r.t., 2 h, 2.) 60 deg C, 29 h

5: 80 percent / NH₃ / methanol / 2 h / Ambient temperature

6: 54 percent / DEAD, PPh₃ / tetrahydrofuran / 15 h / 0 - 20 °C

With 1H-imidazole; ammonia; sodium methylate; triphenylphosphine; 4,4'-diaminostilbene-2,2'-disulfonic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a806562d

Reference yield:

: 218601-14-0
Benzoic acid (3R,4R,5S)-4-hydroxy-5-hydroxymethyl-tetrahydro-thiophen-3-yl ester

: 218601-31-1
9-[(3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-thiophen-3-yl]-6-chloro-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / imidazole / dimethylformamide / 1 h / 0 °C

2: 54 percent / DAST / CH₂Cl₂ / 0.17 h / -4 °C

3: 100 percent / NaOMe / CH₂Cl₂; methanol / 2 h / 0 °C

4: 85 percent / DEAD, PPh₃ / tetrahydrofuran / 1.) r.t., 2 h, 2.) 60 deg C, 29 h

5: 80 percent / NH₃ / methanol / 2 h / Ambient temperature

6: 54 percent / DEAD, PPh₃ / tetrahydrofuran / 15 h / 0 - 20 °C

With 1H-imidazole; ammonia; sodium methylate; triphenylphosphine; 4,4'-diaminostilbene-2,2'-disulfonic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a806562d