((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester
CAS No.:198904-48-2
Molecular Formula:C₂₈H₃₇N₅O₄S
Molecular Weight:539.699
Hs Code.:

Synonyms:((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

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Chemical Property of ((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

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Technology Process of ((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

There total 9 articles about ((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 198904-47-1
N'-[(2S,3S)-2-Hydroxy-3-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyrylamino)-4-phenyl-butyl]-N'-(4-thiazol-5-yl-benzyl)-hydrazinecarboxylic acid tert-butyl ester

: 198904-48-2
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: With formic acid; for 4h; Ambient temperature;
DOI:10.1021/jm970873c

Reference yield:

: 20859-02-3
L-tert-Leucine

: 198904-48-2
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 2N aq. NaOH / dioxane / 18 h / 60 °C

2: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / 1.) DMF, 30 min, 2.) DMF, RT, 3 h

3: 100 percent / H₂CO₂H / 4 h / Ambient temperature

With sodium hydroxide; formic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane;
DOI:10.1021/jm970873c

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 198904-48-2
((S)-1-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-thiazol-5-yl-benzyl)-hydrazino]-propylcarbamoyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / KOAc, Pd(PPh₃)4 / N,N-dimethyl-acetamide / 12 h / 150 °C

2: 92 percent / ethanol / 4 h / Heating

3: 1.) NaCNBH₃, p-TsOH, 2.) aq. NaOH / 1.) THF, RT, 37 h, 2.) THF, reflux, 3.5 h

4: 52 percent / propan-2-ol / 16 h / 80 °C

5: 93 percent / aq. K₂CO₃ / methanol / 3 h / Heating

6: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / 1.) DMF, 30 min, 2.) DMF, RT, 3 h

7: 100 percent / H₂CO₂H / 4 h / Ambient temperature

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; potassium acetate; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; ethanol; N,N-dimethyl acetamide; isopropyl alcohol;
DOI:10.1021/jm970873c