C₅₂H₇₇BrO₇Si₂

Base Information

• Chemical Name: C₅₂H₇₇BrO₇Si₂
• CAS No.: 795306-35-3
• Molecular Formula: C₅₂H₇₇BrO₇Si₂
• Molecular Weight: 950.254
• Mol file: 795306-35-3.mol

Synonyms:C₅₂H₇₇BrO₇Si₂

Chemical Property of C₅₂H₇₇BrO₇Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₂H₇₇BrO₇Si₂

There total 29 articles about C₅₂H₇₇BrO₇Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

[(3R,5S,6S)-7-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-2-oxo-oct-7-enyl]-phosphonic acid diethyl ester (795306-23-9) + C36H48O6Si (795306-78-4) → C52H77BrO7Si2 (795306-35-3)

Guidance literature:

[(3R,5S,6S)-7-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-2-oxo-oct-7-enyl]-phosphonic acid diethyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.166667h;

C₃₆H₄₈O₆Si; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 15h;

DOI:10.1039/b410092a

Reference yield:

(2S,3S)-4-Bromo-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pent-4-en-1-ol (795306-24-0) → C52H77BrO7Si2 (795306-35-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 88 percent / Ph₃P; imidazole; iodine / CH₂Cl₂ / 12 h / 20 °C

2.1: LDA; LiCl / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

2.2: 92 percent / tetrahydrofuran; hexane / 18 h / 0 °C

3.1: 84 percent / LDA; borane-ammonia complex / tetrahydrofuran; hexane / 2 h / 20 °C

4.1: 81 percent / TPAP; 4 Angstroem molecular sieves; NMO / CH₂Cl₂ / 0.5 h / 20 °C

5.1: n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

5.2: 76 percent / tetrahydrofuran / 0.17 h / -78 °C

6.1: 86 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

7.1: KHMDS / tetrahydrofuran; toluene / 0.17 h / -78 °C

7.2: 45 percent / tetrahydrofuran; toluene / 15 h / -78 - 20 °C

With 1H-imidazole; ammonia borane; dipyridinium dichromate; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; iodine; potassium hexamethylsilazane; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; 2.2: Myers alkylation;

DOI:10.1039/b410092a

Reference yield:

[(S)-2-Bromo-1-((R)-2-iodo-1-methyl-ethyl)-allyloxy]-tert-butyl-dimethyl-silane (795306-40-0) → C52H77BrO7Si2 (795306-35-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: LDA; LiCl / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

1.2: 92 percent / tetrahydrofuran; hexane / 18 h / 0 °C

2.1: 84 percent / LDA; borane-ammonia complex / tetrahydrofuran; hexane / 2 h / 20 °C

3.1: 81 percent / TPAP; 4 Angstroem molecular sieves; NMO / CH₂Cl₂ / 0.5 h / 20 °C

4.1: n-BuLi / tetrahydrofuran / 0.17 h / -78 °C

4.2: 76 percent / tetrahydrofuran / 0.17 h / -78 °C

5.1: 86 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

6.1: KHMDS / tetrahydrofuran; toluene / 0.17 h / -78 °C

6.2: 45 percent / tetrahydrofuran; toluene / 15 h / -78 - 20 °C

With ammonia borane; dipyridinium dichromate; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; potassium hexamethylsilazane; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; toluene; 1.2: Myers alkylation;

DOI:10.1039/b410092a

upstream raw materials:

[(3R,5S,6S)-7-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-2-oxo-oct-7-enyl]-phosphonic acid diethyl ester

C₃₆H₄₈O₆Si

(2S,3S)-4-Bromo-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pent-4-en-1-ol

[(S)-2-Bromo-1-((R)-2-iodo-1-methyl-ethyl)-allyloxy]-tert-butyl-dimethyl-silane