N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine

Base Information

Chemical Name:N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine
CAS No.:174894-05-4
Molecular Formula:C₂₅H₃₃N₃O₇S
Molecular Weight:519.619
Hs Code.:

Synonyms:N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine

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Chemical Property of N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine

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Technology Process of N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine

There total 4 articles about N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 3-amidino-D,L-phenylalanine, dihydrochloride salt

: 80745-07-9
4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

: 174894-05-4
N-alpha-Boc-N-omega-4-methoxy-2,3,6-trimethylbenzenesulfonyl-3-amidino-D,L-phenylalanine

Guidance literature:: 3-amidino-D,L-phenylalanine, dihydrochloride salt; With di-tert-butyl dicarbonate; sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 18h;

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride; With sodium hydroxide; at 0 ℃; for 1h; pH=12;

Reference yield:

: 80745-07-9
4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

: 685825-59-6
2-tert-butoxycarbonylamino-3-(3-carbamimidoyl-phenyl)-propionic acid

: 174894-05-4
N-[(1,1-dimethylethoxy)carbonyl]-3-[imino[[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]-D,L-phenylalanine

Guidance literature:: With sodium hydroxide; at 20 ℃; for 3h; pH=12;
DOI:10.1021/jm0303857

Reference yield:

: 52117-05-2
(3-amidinophenyl)-D,L-alanine dihydrochloride

: 174894-05-4
N-[(1,1-dimethylethoxy)carbonyl]-3-[imino[[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]-D,L-phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / dioxane; H₂O / 18 h

2: 3.35 g / aq. NaOH / 3 h / 20 °C / pH 12

With sodium hydroxide; sodium carbonate; In 1,4-dioxane; water;
DOI:10.1021/jm0303857