(+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester

Base Information

• Chemical Name: (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester
• CAS No.: 354759-01-6
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 354759-01-6.mol

Synonyms:(+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester

Chemical Property of (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester

There total 1 articles about (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(+/-)-α-bromo-p-tolylacetic acid ethyl ester (15674-78-9) + hydroxy-3 (pyrrolyl-1)-2 pyridine (102064-28-8) → (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester (354759-01-6)

Guidance literature:

hydroxy-3 (pyrrolyl-1)-2 pyridine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h;

(+/-)-α-bromo-p-tolylacetic acid ethyl ester; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/jm020849l

Reference yield: 97.0%

(+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester (354759-01-6) → (+/-)-α-[3[2-(1H-pyrrol-1-yl)pyridyl]oxy]-p-tolylacetic acid (354759-02-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

DOI:10.1021/jm020849l

Reference yield:

(+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester (354759-01-6) → (+/-)-6-p-tolylpyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one (354759-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / aq. NaOH / ethanol; tetrahydrofuran / 2 h / 20 °C

2: phosphorus pentachloride / CH₂Cl₂ / 7 h / Heating

With sodium hydroxide; phosphorus pentachloride; In tetrahydrofuran; ethanol; dichloromethane; 2: Friedel-Crafts cyclization;

DOI:10.1021/jm020849l

upstream raw materials:

(+/-)-α-bromo-p-tolylacetic acid ethyl ester

hydroxy-3 (pyrrolyl-1)-2 pyridine

Downstream raw materials:

(+/-)-α-[3[2-(1H-pyrrol-1-yl)pyridyl]oxy]-p-tolylacetic acid

(+/-)-6-p-tolylpyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one