C₂₈H₄₂N₄O₅

Base Information

• Chemical Name: C₂₈H₄₂N₄O₅
• CAS No.: 1353742-71-8
• Molecular Formula: C₂₈H₄₂N₄O₅
• Molecular Weight: 514.665
• Mol file: 1353742-71-8.mol

Synonyms:C₂₈H₄₂N₄O₅

Chemical Property of C₂₈H₄₂N₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₂₈H₄₂N₄O₅

There total 5 articles about C₂₈H₄₂N₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C17H22N2O5 (1353742-55-8) + C2HF3O2*C11H22N2O (1353742-70-7) → C28H42N4O5 (1353742-71-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1039/c1ob06575k

Reference yield:

2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid (221158-93-6) → C28H42N4O5 (1353742-71-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 0 °C

2.2: pH 2

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/c1ob06575k

Reference yield:

C19H28N2O3 (1353742-77-4) → C28H42N4O5 (1353742-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 % Pd(OH)2/C; hydrogen / ethyl acetate / 4 h / 20 °C / 4560.31 - 5320.36 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

With 20 % Pd(OH)2/C; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/c1ob06575k

upstream raw materials:

C₁₈H₂₄N₂O₅

C₁₇H₂₂N₂O₅

C₂HF₃O₂*C₁₁H₂₂N₂O

C₁₉H₂₈N₂O₃