Technology Process of 1-fluoro-5-(3-fluorophenyl)-2-methyl-3-nitrobenzene
There total 1 articles about 1-fluoro-5-(3-fluorophenyl)-2-methyl-3-nitrobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane; ethanol;
at 80 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 48 h
2: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C
3: potassium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / tetrahydrofuran / 16 h / 125 °C / 37503.8 Torr
4: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
6: potassium carbonate / tetrahydrofuran / 2 h / 0 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; tert.-butylnitrite; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; potassium acetate; palladium diacetate; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; copper(ll) bromide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 48 h
2: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 0 °C
3: potassium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / tetrahydrofuran / 16 h / 125 °C / 37503.8 Torr
4: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C
5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C
6: potassium carbonate / tetrahydrofuran / 2 h / 0 °C
7: borane-THF / tetrahydrofuran / Inert atmosphere; Reflux
With
1,1'-bis-(diphenylphosphino)ferrocene; tert.-butylnitrite; borane-THF; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; potassium acetate; palladium diacetate; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; copper(ll) bromide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
