1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Base Information

Chemical Name:1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione
CAS No.:1448800-45-0
Molecular Formula:C₂₂H₁₄F₃N₃O₂
Molecular Weight:409.367
Hs Code.:

Synonyms:1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

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Chemical Property of 1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

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Technology Process of 1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

There total 4 articles about 1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1448800-22-3
7-bromo-1,3-dimethyl-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

: 536-74-3
phenylacetylene

: 1448800-45-0
1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 20 ℃; for 51h;
DOI:10.1039/c3ob26837c

Reference yield:

: 1448799-95-8
6-[(4-bromophenyl)amino]-1,3-dimethyl-5-(trifluoroacetyl)pyrimidine-2,4(1H,3H)-dione

: 1448800-45-0
1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 3 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 51 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; diisopropylamine; In tetrahydrofuran; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob26837c

Reference yield:

: 64663-99-6
6-(4-bromo-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione

: 1448800-45-0
1,3-dimethyl-7-(phenylethynyl)-5-(trifluoromethyl)pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1,4-dioxane / 20 °C

2: sulfuric acid / 3 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 51 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob26837c