3-Oxo-(-)-lentiginosine

Base Information

Chemical Name:3-Oxo-(-)-lentiginosine
CAS No.:160169-49-3
Molecular Formula:C₈H₁₃NO₃
Molecular Weight:171.196
Hs Code.:
DSSTox Substance ID:DTXSID60461178
Wikidata:Q82285440
Mol file:160169-49-3.mol

Synonyms:3-Oxo-(-)-lentiginosine;160169-49-3;(1R,2S,8aR)-1,2-dihydroxy-2,5,6,7,8,8a-hexahydro-1H-indolizin-3-one;3(2H)-Indolizinone, hexahydro-1,2-dihydroxy-, (1R,2S,8aR)-;DTXSID60461178;AKOS030241123;J-009690;(1R,2S,8aR)-1,2-dihydroxy-octahydroindolizin-3-one

Suppliers and Price of 3-Oxo-(-)-lentiginosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Oxo-(-)-lentiginosine
5mg
$ 265.00

TRC
3-Oxo-(-)-lentiginosine
1mg
$ 110.00

American Custom Chemicals Corporation
3-OXO-(-)-LENTIGINOSINE 95.00%
5MG
$ 505.58

American Custom Chemicals Corporation
3-OXO-(-)-LENTIGINOSINE 95.00%
1MG
$ 349.65

Total 3 raw suppliers

Chemical Property of 3-Oxo-(-)-lentiginosine

Chemical Property:

Boiling Point:357.7±42.0 °C(Predicted)
PKA:13.13±0.40(Predicted)
PSA：60.77000
Density:1.37±0.1 g/cm3(Predicted)
LogP:-0.95920
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:171.08954328
Heavy Atom Count:12
Complexity:207

Purity/Quality:

97% ^*data from raw suppliers

3-Oxo-(-)-lentiginosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN2C(C1)C(C(C2=O)O)O
Isomeric SMILES:C1CCN2[C@H](C1)[C@H]([C@@H](C2=O)O)O

Technology Process of 3-Oxo-(-)-lentiginosine

There total 19 articles about 3-Oxo-(-)-lentiginosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₂₇NO₆

: 160169-49-3
(1R,2S,8aR)-1,2-dihydroxy-hexahydroindolizin-3(5H)-one

Guidance literature:: C₁₅H₂₇NO₆; With trifluoroacetic acid; for 10h;

In ethanol; for 6h; Reflux;

With triethylamine; In methanol; chloroform;
DOI:10.1016/j.tet.2010.11.011

Reference yield:

: 160096-51-5,160169-48-2
(R)-2-((1R,2S)-2-Ethoxycarbonyl-1,2-dihydroxy-ethyl)-piperidine-1-carboxylic acid benzyl ester

: 160169-49-3
(1R,2S,8aR)-1,2-dihydroxy-hexahydroindolizin-3(5H)-one

Guidance literature:: With hydrogen; sodium acetate; palladium on activated charcoal; In methanol; for 12h; under 760 Torr;
DOI:10.1016/S0040-4039(00)78520-0

Reference yield:

: 839711-89-6
(2S,3R)-isopropyl 2,3-dihydroxy-3-(N-oxypyridin-2-yl)propanoate

: 160169-49-3
(1R,2S,8aR)-1,2-dihydroxy-hexahydroindolizin-3(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / H₂ / PtO₂*H₂O / methanol / 336 h

2: TBAF

With tetrabutyl ammonium fluoride; hydrogen; platinum(IV) oxide; In methanol;
DOI:10.1016/j.tet.2004.10.086