dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Base Information

Chemical Name:dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate
CAS No.:176208-41-6
Molecular Formula:C₂₃H₂₅N₃O₆S
Molecular Weight:471.534
Hs Code.:

Synonyms:dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Chemical Property of dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

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Technology Process of dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

There total 4 articles about dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6525-53-7,16422-27-8,40149-68-6
L-glutamic acid dimethyl ester

: 176208-37-0
4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

: 176208-41-6
dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.3987/com-95-7269

Reference yield:

: 149010-52-6
1-chloro-4-(4-carbomethoxyphenyl)-2-butanone

: 176208-41-6
dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / 1.) NaSH; 2.) Et₃N / methanol / 1.) -10 deg C, 2 h; 2.) -5 - 5 deg C, 3 h

2: 40 percent / HCl(g) / 80 h / 25 °C

3: 66 percent / 1N NaOH / methanol / 90 h / Heating

4: 81 percent / 6-chloro-2,4-dimethoxy-1,3,5-triazine, N-methylmorpholine (NMM) / dimethylformamide / 12 h / 25 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium hydrogensulfide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-95-7269

Reference yield:

: 176208-33-6
methyl 4-<2-<2-amino-3-carbomethoxythiophen-4-yl>ethyl>benzoate

: 176208-41-6
dimethyl N-<4-<2-(2-methyl-4(3H)-oxothieno<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / HCl(g) / 80 h / 25 °C

2: 66 percent / 1N NaOH / methanol / 90 h / Heating

3: 81 percent / 6-chloro-2,4-dimethoxy-1,3,5-triazine, N-methylmorpholine (NMM) / dimethylformamide / 12 h / 25 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-95-7269