p-tolyl p-tolylthioprop-1-enyl sulfone

Base Information

• Chemical Name: p-tolyl p-tolylthioprop-1-enyl sulfone
• CAS No.: 156808-53-6
• Molecular Formula: C₁₇H₁₈O₂S₂
• Molecular Weight: 318.461
• Mol file: 156808-53-6.mol

Synonyms:p-tolyl p-tolylthioprop-1-enyl sulfone

Chemical Property of p-tolyl p-tolylthioprop-1-enyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-tolyl p-tolylthioprop-1-enyl sulfone

There total 9 articles about p-tolyl p-tolylthioprop-1-enyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C17H20O3S2 (201664-67-7) → p-tolyl p-tolylthioprop-1-enyl sulfone (156808-53-6)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(97)10472-5

Reference yield: 63.0%

2-hydroxy-p-tolylthiopropyl p-tolyl sulfone → p-tolyl p-tolylthioprop-1-enyl sulfone (156808-53-6)

Guidance literature:

With dmap; acetic anhydride; In pyridine; at 18 ℃; for 24h;

Reference yield:

1-(isopropylsulfinyl)-4-methylbenzene (1517-74-4,37067-60-0,67529-35-5,50337-53-6) → p-tolyl p-tolylthioprop-1-enyl sulfone (156808-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK, H(+)

2: 90 percent / KH / dimethylformamide / Ambient temperature

3: 95 percent / TMSOTf, i-Pr₂NEt / CH₂Cl₂ / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; hydrogen cation; potassium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(97)10472-5

upstream raw materials:

C₁₇H₂₀O₃S₂

1-(isopropylsulfinyl)-4-methylbenzene

(p-Toluolsulfinylmethyl)-p-toluylsulfon

p-CH₃C₆H₄SO₂CH₂Li

Downstream raw materials:

p-tolyl 1-p-tolylthioallyl sulfone

4-Methyl-N-[1-methyl-2-(toluene-4-sulfonyl)-2-p-tolylsulfanyl-ethyl]-N-((E)-3-phenyl-allyl)-benzenesulfonamide

Refernces

• 1、 Fox, Judith M.,Morris, Clare M.,Smyth, G. Darren,Whitman, Gordon H.. "Radical-induced 1,3-Rearrangemets of Allylic Sulfones bearing an Alkylthio or Arylthio Substituent at the α-Position". . p. 731 - 738. Retrieved 2007/10/02.