tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

Base Information

Chemical Name:tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate
CAS No.:1275592-81-8
Molecular Formula:C₄₀H₄₇NO₄Si
Molecular Weight:633.903
Hs Code.:

Synonyms:tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

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Chemical Property of tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

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Technology Process of tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

There total 1 articles about tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1275592-79-4
1-benzyloxy-6-tert-butyldiphenylsilyloxy-4-tributylstannylhexa-2,3-diene

: 161117-84-6
tert-butyl 2-iodophenylcarbamate

: 1275592-81-8
tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; trifuran-2-yl-phosphane; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ol200320z

Reference yield:

: 1275592-81-8
tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

: 1275592-80-7
tert-butyl 3-(2-tert-butyldiphenylsiloxyethyl)-2-vinyl-1H-indole-1-carboxylate

: 1275592-82-9
tert-butyl 2-(2-benzyloxyethyl)-3-(2-tert-butyldiphenylsiloxyethyl)-1H-indole-1-carboxylate

Guidance literature:: With potassium carbonate; In ethanol; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ol200320z

Reference yield:

: 1275592-81-8
tert-butyl N-2-(6-benzyloxy-1-tert-butyldiphenylsilyloxyhexa-3,4-dien-3-yl)phenylcarbamate

: 1275592-97-6
(S)-2-{(4aS,12aR)-7-(2-tert-butyldiphenylsilyloxyethyl)-4a-ethyl-1,2,3,4,4a,5,6,12a-octahydroindolo[1,2-a][1,8]naphthyridin-1-yl}-2-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / ethanol / 5 h / 20 °C / Inert atmosphere

2.1: Hoveyda-Grubbs catalyst second generation / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 140 °C / Inert atmosphere

3.1: 5% Pd(II)/C(eggshell); hydrogen / ethyl acetate / 27 h / 20 °C / 760.05 Torr

4.1: sodium hydride / diethyl ether; oil / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; 5% Pd(II)/C(eggshell); hydrogen; sodium hydride; potassium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; ethanol; ethyl acetate; oil;
DOI:10.1021/ol200320z