ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Base Information

Chemical Name:ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol
CAS No.:1263324-60-2
Molecular Formula:C₂₅H₂₄O
Molecular Weight:340.465
Hs Code.:

Synonyms:ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Suppliers and Price of ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

There total 5 articles about ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1263324-57-7
2-ethyl-3-(1-phenylallyl)spiro[cyclopropane-1,9'-fluorene]

: 1263324-60-2
ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Guidance literature:: 2-ethyl-3-(1-phenylallyl)spiro[cyclopropane-1,9'-fluorene]; With ozone; In dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol1029904

Reference yield:

: 1263324-61-3
spiro[2-trimethylsilylcycloprop-2-ene-1,9'-fluorene]

: 1263324-60-2
ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

2.1: dichloro bis(acetonitrile) palladium(II); zinc trifluoromethanesulfonate; (R)-tol-BINAP / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 5 h / -78 - 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / -78 °C

3.2: -78 - 20 °C

With dichloro bis(acetonitrile) palladium(II); tetrabutyl ammonium fluoride; zinc trifluoromethanesulfonate; ozone; (R)-tol-BINAP; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol1029904

Reference yield:

: 1263324-40-8
spiro[cycloprop-2-ene-1,9'-fluorene]

: 1263324-60-2
ethylspiro[cyclopropane-1,9'-fluoren-3-yl]2-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloro bis(acetonitrile) palladium(II); zinc trifluoromethanesulfonate; (R)-tol-BINAP / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

1.2: 5 h / -78 - 20 °C / Inert atmosphere

2.1: ozone / dichloromethane / -78 °C

2.2: -78 - 20 °C

With dichloro bis(acetonitrile) palladium(II); zinc trifluoromethanesulfonate; ozone; (R)-tol-BINAP; In dichloromethane;
DOI:10.1021/ol1029904