ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Chemical Name:ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate
CAS No.:1228588-22-4
Molecular Formula:C₂₅H₃₆N₆O₅
Molecular Weight:500.598
Hs Code.:

Synonyms:ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Chemical Property of ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

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Technology Process of ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

There total 5 articles about ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228588-21-3
C₂₂H₃₀N₆O₆S

: 71-36-3
butan-1-ol

: 1228588-22-4
ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: With trifluoroacetic acid; at 95 - 100 ℃; for 5.5h;

Reference yield:

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1228588-22-4
ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1.25 h / 23 °C

2: triethylamine / tetrahydrofuran / -78 - 23 °C

3: acetic acid; dihydrogen peroxide; sodium tungstate (VI) dihydrate / ethanol / 0 °C

4: trifluoroacetic acid / 5.5 h / 95 - 100 °C

With sodium tungstate (VI) dihydrate; dihydrogen peroxide; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm400815m

Reference yield:

: 1228588-19-9
ethyl-Nβ-[3-(pyrroldin-1′-ylmethyl)-benzyl]-β-alaninoate

: 1228588-22-4
ethyl-Nβ-[4-amino-2-n-butoxy-5-nitropyrimidin-6-yl],Nβ-[3′-(pyrrolidin-1″-ylmethyl)-benzyl]-β-alaninoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / -78 - 23 °C

2: acetic acid; dihydrogen peroxide; sodium tungstate (VI) dihydrate / ethanol / 0 °C

3: trifluoroacetic acid / 5.5 h / 95 - 100 °C

With sodium tungstate (VI) dihydrate; dihydrogen peroxide; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol;
DOI:10.1021/jm400815m