6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE
• CAS No.: 159981-19-8
• Molecular Formula: C8H6 F3 N O2
• Molecular Weight: 205.13
• Mol file: 159981-19-8.mol

Synonyms:6-(2,2,2-Trifluoroethoxy)pyridine-3-carboxaldehyde

Chemical Property of 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0392mmHg at 25°C
• Refractive Index: 1.478
• Boiling Point: 239.8°C at 760 mmHg
• PKA: 0.97±0.22(Predicted)
• Flash Point: 98.9°C
• PSA: 39.19000
• Density: 1.356g/cm³
• LogP: 1.83520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-(2,2,2-Trifluoro-ethoxy)-pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41-43
• Safety Statements: 26-36/37-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE

There total 5 articles about 6-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

→ 6-(2,2,2-trifluoroethoxy)pyridine-3-carbaldehyde (159981-19-8)

Guidance literature:

Reference yield:

N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide (1373862-15-7) → 6-(2,2,2-trifluoroethoxy)pyridine-3-carbaldehyde (159981-19-8)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]methanol → 6-(2,2,2-trifluoroethoxy)pyridine-3-carbaldehyde (159981-19-8)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

N-methoxy-N-methyl-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide

6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

6-Chloronicotinic acid methyl ester