TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER

Base Information

• Chemical Name: TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER
• CAS No.: 159974-55-7
• Molecular Formula: C12H15 N O5 S
• Molecular Weight: 285.321
• Hs Code.: 2934999090
• Mol file: 159974-55-7.mol

Synonyms:Toluene-4-sulfonicacid 2-(2-oxooxazolidin-3-yl)ethyl ester

Chemical Property of TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER

Chemical Property:

• Melting Point: 68-69°
• Boiling Point: 528.7±33.0 °C(Predicted)
• PKA: -1.61±0.20(Predicted)
• PSA: 81.29000
• Density: 1.335±0.06 g/cm3(Predicted)
• LogP: 2.17120

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Oxo-1,3-oxazolan-3-yl)ethyl4-methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER

There total 1 articles about TOLUENE-4-SULFONIC ACID 2-(2-OXO-OXAZOLIDIN-3-YL)-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-(2'-hydroxyethyl)-2-oxazolidone (3356-88-5) + p-toluenesulfonyl chloride (98-59-9) → 4-methylbenzenesulfonic acid-2-(2-oxazolidinone-3-yl)ethyl ester (159974-55-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 22 ℃; for 3h;

DOI:10.1016/0040-4039(94)85306-1

Reference yield: 97.0%

methyl 4-{(4E)-5-(2-hydroxyphenyl)-3-[4-(methoxycarbonyl)benzyl]pent-4-en-1-yl}benzoate (1065269-98-8) + 4-methylbenzenesulfonic acid-2-(2-oxazolidinone-3-yl)ethyl ester (159974-55-7) → Methyl 4-[(4E)-3-[4-(methoxycarbonyl)benzyl]-5-{2-[2-(2-oxo-1,3-oxazolidin-3-yl)ethoxy]-phenyl}pent-4-en-1-yl]benzoate (1273326-48-9)

Guidance literature:

With caesium carbonate; In toluene; at 60 ℃; for 18h;

Reference yield:

C24H27N3O3 + 4-methylbenzenesulfonic acid-2-(2-oxazolidinone-3-yl)ethyl ester (159974-55-7) → C29H34N4O5

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 72h; Inert atmosphere;

upstream raw materials:

N-(2'-hydroxyethyl)-2-oxazolidone

p-toluenesulfonyl chloride

Downstream raw materials:

3-(2-Cyclohexylamino-ethyl)-oxazolidin-2-one

3-[2-(4-Methoxy-phenylamino)-ethyl]-oxazolidin-2-one

3-(2-anilino-ethyl)-oxazolidin-2-one

2-[2-(2-Oxo-oxazolidin-3-yl)-ethylamino]-benzoic acid methyl ester