4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

Base Information

Chemical Name:4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide
CAS No.:1443732-74-8
Molecular Formula:C₂₃H₂₁F₂N₃O₃S
Molecular Weight:457.501
Hs Code.:

Synonyms:4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

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Chemical Property of 4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

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Technology Process of 4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

There total 7 articles about 4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 957034-82-1
(4-(N,N-dimethylsulfamoyl)-2-methylphenyl)boronic acid

: 1443732-86-2
5-chloro-2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridine

: 1443732-74-8
4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1443732-81-7
5-chloro-2-ethoxycarbonyloxypyrrolo[3,2-b]pyridine-1-carboxylic acid ethyl ester

: 1443732-74-8
4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium carbonate / N,N-dimethyl-formamide / 0.58 h / 0 - 20 °C

2: diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / 110 °C / Inert atmosphere

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 110 °C / Inert atmosphere

With ammonium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4: |Suzuki Coupling;

Reference yield:

: 5-chloro-2-hydroxypyrrolo[3,2-b]pyridine-1-carboxylic acid ethyl ester

: 1443732-74-8
4-(2-(2,6-difluoro-4-methoxyphenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)-N,N,3-trimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 16 h / 110 °C / Inert atmosphere

3: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; 3: |Suzuki Coupling;