C₁₉H₂₆N₂O₄

Base Information

• Chemical Name: C₁₉H₂₆N₂O₄
• CAS No.: 1239589-54-8
• Molecular Formula: C₁₉H₂₆N₂O₄
• Molecular Weight: 346.426
• Mol file: 1239589-54-8.mol

Synonyms:C₁₉H₂₆N₂O₄

Chemical Property of C₁₉H₂₆N₂O₄

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₆N₂O₄

There total 3 articles about C₁₉H₂₆N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-[(tert-butoxy)carbonyl]-2-azaspiro[3.3]heptane-6-carboxylic acid (1211526-53-2) + benzyl alcohol (100-51-6,185532-71-2) → C19H26N2O4 (1239589-54-8)

Guidance literature:

2-[(tert-butoxy)carbonyl]-2-azaspiro[3.3]heptane-6-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 95 ℃;

benzyl alcohol; In toluene; at 95 ℃; for 16h;

DOI:10.1021/jo101271h

Reference yield:

→ C19H26N2O4 (1239589-54-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield:

tert-butyl 6-azido-2-azaspiro[3.3]heptane-2-carboxylate (1239320-12-7) → C19H26N2O4 (1239589-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2: Sodium hydrogenocarbonate / lithium hydroxide monohydrate; toluene / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; Sodium hydrogenocarbonate; In ethanol; lithium hydroxide monohydrate; toluene;

upstream raw materials:

2-[(tert-butoxy)carbonyl]-2-azaspiro[3.3]heptane-6-carboxylic acid

benzyl alcohol

tert-butyl 6-azido-2-azaspiro[3.3]heptane-2-carboxylate

Downstream raw materials:

6-amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE". Page/Page column 88; 93. . Retrieved 2014/01/08.