3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Base Information

• Chemical Name: 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester
• CAS No.: 202413-55-6
• Molecular Formula: C₄₁H₅₄O₆
• Molecular Weight: 642.876
• Mol file: 202413-55-6.mol

Synonyms:3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Chemical Property of 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester

There total 3 articles about 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate (111247-96-2) + S-tert-butyl 3-oxo-octadecanethioate (185430-10-8) → 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester (202413-55-6)

Guidance literature:

With silver trifluoroacetate; In tetrahydrofuran; at 23 ℃;

DOI:10.1016/S0040-4039(96)02029-1

Reference yield:

trityl chloride (76-83-5) → 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester (202413-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃, DMAP / 23 °C

2: 74 percent / CF₃COOAg / tetrahydrofuran / 23 °C

With dmap; silver trifluoroacetate; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(96)02029-1

Reference yield:

1-hexadecylcarboxylic acid (57-10-3) → 3-Oxo-octadecanoic acid (S)-1-methoxycarbonyl-2-trityloxy-ethyl ester (202413-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / CDI / tetrahydrofuran / 23 °C

2: 74 percent / CF₃COOAg / tetrahydrofuran / 23 °C

With silver trifluoroacetate; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1016/S0040-4039(96)02029-1

upstream raw materials:

methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate

S-tert-butyl 3-oxo-octadecanethioate

trityl chloride

1-hexadecylcarboxylic acid

Downstream raw materials:

(S)-3-Hexadecanoyl-4-hydroxy-5-trityloxymethyl-5H-furan-2-one