N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide

Base Information

• Chemical Name: N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide
• CAS No.: 1305340-09-3
• Molecular Formula: C₂₀H₁₇F₃N₂O₃
• Molecular Weight: 390.362

Synonyms:N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide

Chemical Property of N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide

Chemical Property:

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Technology Process of N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide

There total 1 articles about N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide (312615-59-1) + benzylamine (100-46-9) → N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide (1305340-09-3)

Guidance literature:

In N,N-dimethyl-formamide; at 80 - 90 ℃; for 8h;

DOI:10.1055/s-0030-1258448

Reference yield: 64.0%

N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide (1305340-09-3) → C20H19F3N2O3 + C20H19F3N2O3

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In tetrahydrofuran; at 25 ℃; for 8h; under 30402 Torr; Autoclave;

DOI:10.1055/s-0030-1258448

Reference yield:

N-[1-benzyl-6-hydroxy-2-oxo-6-(trifluoromethyl)-1,2,5,6-tetrahydropyridin-3-yl]benzamide (1305340-09-3) → 1-benzyl-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl-N-benzamide

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Reflux;

DOI:10.1055/s-0030-1258448

upstream raw materials:

2-oxo-6-trifluoromethyl-2H-pyran-3-yl-N-benzamide

benzylamine

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