3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

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Chemical Name:3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid
CAS No.:1186188-44-2
Molecular Formula:C₂₂H₁₈N₂O₅
Molecular Weight:390.395
Hs Code.:

Synonyms:3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

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Chemical Property of 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

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Technology Process of 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

There total 6 articles about 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1186188-43-1
ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

: 1186188-44-2
3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 6315-94-2
ethyl 2,4-dichloroquinoline-3-carboxylate

: 1186188-44-2
3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate / acetic acid / 20?h / 120?°C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 15?min / Cooling with ice

2.2: 1 h / Cooling with ice

3.1: triethylamine / ethanol / 12 h / 85 °C

4.1: sodium ethanolate / ethanol / 18 h / 50 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 4 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; ethanol / 18 h / 20 °C

With sodium ethanolate; sodium acetate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.039

Reference yield:

: 1186188-42-0
ethyl 3-hydroxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

: 1186188-44-2
3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 4 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol / 18 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.039