5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

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Chemical Name:5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one
CAS No.:178551-09-2
Molecular Formula:C₁₆H₁₈N₂O₃S
Molecular Weight:318.397
Hs Code.:

Synonyms:5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

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Chemical Property of 5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

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Technology Process of 5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

There total 3 articles about 5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 178551-07-0
Benzoic acid (2S,5R)-5-(5-benzyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 178551-09-2
5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / Lawesson reagent / 1,2-dichloro-ethane / 3 h / Heating

2: 74 percent / NH₃ / methanol / 72 h / Ambient temperature

With Lawessons reagent; ammonia; In methanol; 1,2-dichloro-ethane;
DOI:10.1135/cccc19960627

Reference yield:

: 178551-06-9
Benzoic acid (2R,3S,5R)-5-(5-benzyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

: 178551-09-2
5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂, 2.) tributylstannane, azobis(isobutyronitrile) / 1.) HMTA, room temp., overnight, 2.) toluene, reflux, 1 h

2: 77 percent / Lawesson reagent / 1,2-dichloro-ethane / 3 h / Heating

3: 74 percent / NH₃ / methanol / 72 h / Ambient temperature

With Lawessons reagent; thionyl chloride; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; In methanol; 1,2-dichloro-ethane;
DOI:10.1135/cccc19960627

Reference yield:

: 1027173-04-1
Benzoic acid (2R,3R,4R,5R)-5-(5-benzyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-chloro-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

: 178551-09-2
5-Benzyl-1-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: tributylstannane, azobis(isobutyronitrile) / toluene / 0.33 h / Heating

2: 1.) SOCl₂, 2.) tributylstannane, azobis(isobutyronitrile) / 1.) HMTA, room temp., overnight, 2.) toluene, reflux, 1 h

3: 77 percent / Lawesson reagent / 1,2-dichloro-ethane / 3 h / Heating

4: 74 percent / NH₃ / methanol / 72 h / Ambient temperature

With Lawessons reagent; thionyl chloride; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; In methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1135/cccc19960627