Technology Process of (S)-2-[(1R,2S)-2-Acetoxy-1-(4-methoxy-benzyloxy)-3-oxo-propyl]-aziridine-1-carboxylic acid benzyl ester
There total 12 articles about (S)-2-[(1R,2S)-2-Acetoxy-1-(4-methoxy-benzyloxy)-3-oxo-propyl]-aziridine-1-carboxylic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 90 percent / L-(+)-DIPT; t-BuOOH; Ti(O-i-Pr)4 / -10 °C
2.1: 84 percent / NaH
3.1: 74 percent / NaN3; aq. NH4Cl / 2-methoxy-ethanol
4.1: Ph3P; H2O / toluene
5.1: Et3N
6.1: 96 percent / Et3N
7.1: 74 percent / HCl; MeOH
8.1: 99 percent / pyridine
9.1: 100 percent / KO-t-Bu / tetrahydrofuran / -50 °C
10.1: O3
10.2: (CH3)2S
With
pyridine; titanium(IV) isopropylate; hydrogenchloride; methanol; tert.-butylhydroperoxide; sodium azide; L-(+)-diisopropyl tartrate; potassium tert-butylate; water; sodium hydride; ammonium chloride; ozone; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 2-methoxy-ethanol; toluene;
1.1: asymmetric epoxidation / 2.1: Alkylation / 3.1: Addition / 4.1: Reduction / 5.1: N-acylation / 6.1: mesylation / 7.1: methanolysis / 8.1: Acetylation / 9.1: Cyclization / 10.1: ozonization / 10.2: Reduction;
DOI:10.1021/ja992274w
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 84 percent / NaH
2.1: 74 percent / NaN3; aq. NH4Cl / 2-methoxy-ethanol
3.1: Ph3P; H2O / toluene
4.1: Et3N
5.1: 96 percent / Et3N
6.1: 74 percent / HCl; MeOH
7.1: 99 percent / pyridine
8.1: 100 percent / KO-t-Bu / tetrahydrofuran / -50 °C
9.1: O3
9.2: (CH3)2S
With
pyridine; hydrogenchloride; methanol; sodium azide; potassium tert-butylate; water; sodium hydride; ammonium chloride; ozone; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 2-methoxy-ethanol; toluene;
1.1: Alkylation / 2.1: Addition / 3.1: Reduction / 4.1: N-acylation / 5.1: mesylation / 6.1: methanolysis / 7.1: Acetylation / 8.1: Cyclization / 9.1: ozonization / 9.2: Reduction;
DOI:10.1021/ja992274w
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: Ph3P; H2O / toluene
2.1: Et3N
3.1: 96 percent / Et3N
4.1: 74 percent / HCl; MeOH
5.1: 99 percent / pyridine
6.1: 100 percent / KO-t-Bu / tetrahydrofuran / -50 °C
7.1: O3
7.2: (CH3)2S
With
pyridine; hydrogenchloride; methanol; potassium tert-butylate; water; ozone; triethylamine; triphenylphosphine;
In
tetrahydrofuran; toluene;
1.1: Reduction / 2.1: N-acylation / 3.1: mesylation / 4.1: methanolysis / 5.1: Acetylation / 6.1: Cyclization / 7.1: ozonization / 7.2: Reduction;
DOI:10.1021/ja992274w
