1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Base Information

• Chemical Name: 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone
• CAS No.: 196622-26-1
• Molecular Formula: C₃₅H₂₈NOP
• Molecular Weight: 509.587
• Mol file: 196622-26-1.mol

Synonyms:1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Chemical Property of 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone

There total 4 articles about 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-Benzyl-2-[2-ethoxycarbonyl-2-(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid (196622-31-8) → 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (196622-26-1)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

DOI:10.3987/COM-97-7879

Reference yield: 74.0%

1-Benzyl-2-[2-(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid (196622-20-5) → 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (196622-26-1)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

DOI:10.3987/COM-97-7879

Reference yield:

Methylenetriphenylphosphorane (19493-09-5) → 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (196622-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / tetrahydrofuran / 1 h / 0 °C

2: 74 percent / 20percent hydrochloric acid / H₂O / 2 h / Heating

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.3987/COM-97-7879

upstream raw materials:

1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

1-Benzyl-2-[2-ethoxycarbonyl-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

Methylenetriphenylphosphorane

1-benzylindole-2,3-dicarboxylic anhydride

Downstream raw materials:

1-(1-benzylindol-2-yl)-2-buten-1-one