(αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile

Base Information

Chemical Name:(αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile
CAS No.:155203-01-3
Molecular Formula:C₂₇H₃₄N₂O₄
Molecular Weight:450.578
Hs Code.:

Synonyms:17-cyano-4,5α-epoxy-6α,14α-etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-3,6β-dimethoxymorphinan

Suppliers and Price of (αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile

Chemical Property:

Purity/Quality:

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Useful:

Uses (αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-trimethylpropyl)-3,6-dimethoxy-6,14-ethenomorphinan-17-carbonitrile is an intermediate in the synthesis of 18,19-Dehydrobuprenorphine (D229310), an analogue of Buprenorphine (B689570).

Technology Process of (αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile

There total 3 articles about (αS,5α,7α)-4,5-Epoxy-7-(1-hydroxy-1,2,2-triMethylpropyl)-3,6-diMethoxy-6,14-ethenoMorphinan-17-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 506-68-3
bromocyane

: 13965-70-3
4,5α-epoxy-6α,14α-etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-3,6β-dimethoxy-17-methylmorphinan

: 155203-01-3
17-cyano-4,5α-epoxy-6α,14α-etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-3,6β-dimethoxymorphinan

Guidance literature:: With potassium carbonate; In dichloromethane; acetonitrile; at 20 - 40 ℃; for 6h;

Reference yield:

: 15358-22-2
thevinone

: 155203-01-3
17-cyano-4,5α-epoxy-6α,14α-etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-3,6β-dimethoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / diethyl ether; various solvent(s) / 3 h / Heating

2: 89 percent / CHCl₃ / 18 h / Heating

In diethyl ether; chloroform;
DOI:10.3987/com-00-s(i)46

Reference yield:

: 115-37-7
thebaine

: 155203-01-3
17-cyano-4,5α-epoxy-6α,14α-etheno-7α-(1-hydroxy-1,2,2-trimethylpropyl)-3,6β-dimethoxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol; water / 16 h / 60 °C

2: diethyl ether; toluene; diethylene glycol dimethyl ether / 1.5 h / 0 - 10 °C

3: potassium carbonate / acetonitrile; dichloromethane / 6 h / 20 - 40 °C

With potassium carbonate; In diethyl ether; dichloromethane; diethylene glycol dimethyl ether; water; isopropyl alcohol; toluene; acetonitrile;