[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

Base Information

Chemical Name:[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid
CAS No.:1290053-82-5
Molecular Formula:C₂₀H₂₅BN₂O₃
Molecular Weight:352.241
Hs Code.:

Synonyms:[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

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Chemical Property of [3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

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Technology Process of [3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

There total 10 articles about [3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1290056-75-5
benzyl 3-(1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

: 1290053-82-5
[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

Guidance literature:: With hydrogen bromide; In dichloromethane; acetic acid; at 0 - 20 ℃; for 2.5h; Product distribution / selectivity;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1290053-82-5
[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -100 °C

1.2: 5 h / -100 - 20 °C

2.1: pyridine; trichlorophosphate / 72 h / 0 - 20 °C

3.1: hydrogen / palladium(II) hydroxide / ethanol / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 0 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

6.2: 20 °C

7.1: hydrogen bromide / dichloromethane; acetic acid / 2.5 h / 0 - 20 °C

With pyridine; n-butyllithium; hydrogen bromide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; trifluoroacetic acid; trichlorophosphate; palladium(II) hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 370864-42-9
4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1290053-82-5
[3-(2-{4-[3-(aminomethyl)phenyl]piperidin-1-yl}-2-oxoethyl)phenyl]boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium(II) hydroxide / ethanol / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 20 °C

5.1: hydrogen bromide / dichloromethane; acetic acid / 2.5 h / 0 - 20 °C

With hydrogen bromide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; trifluoroacetic acid; palladium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;