(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

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Chemical Name:(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran
CAS No.:1288996-94-0
Molecular Formula:C₃₃H₂₆Br₂O₅
Molecular Weight:662.374
Hs Code.:

Synonyms:(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

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Chemical Property of (2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

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Technology Process of (2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

There total 3 articles about (2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 586-75-4
4-chlorobenzoyl chloride

: 227289-51-2
5,6-dehydro-4-de-O-methylcentrolobin

: 1288996-94-0
(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo2002787

Reference yield:

: 1202784-98-2
(R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran

: 1288996-94-0
(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; palladium diacetate / acetonitrile / 3 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium acetate; palladium diacetate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Mizoroki-Heck reaction;
DOI:10.1021/jo2002787

Reference yield:

: 1288996-76-8
4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)phenol

: 1288996-94-0
(2S,6R)-2-(4-(4'-bromophenylcarboxy)phenylethyl)-6-(4-(4''-bromophenylcarboxy)-phenyl)-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo2002787